221 research outputs found
Network synchronization: Optimal and Pessimal Scale-Free Topologies
By employing a recently introduced optimization algorithm we explicitely
design optimally synchronizable (unweighted) networks for any given scale-free
degree distribution. We explore how the optimization process affects
degree-degree correlations and observe a generic tendency towards
disassortativity. Still, we show that there is not a one-to-one correspondence
between synchronizability and disassortativity. On the other hand, we study the
nature of optimally un-synchronizable networks, that is, networks whose
topology minimizes the range of stability of the synchronous state. The
resulting ``pessimal networks'' turn out to have a highly assortative
string-like structure. We also derive a rigorous lower bound for the Laplacian
eigenvalue ratio controlling synchronizability, which helps understanding the
impact of degree correlations on network synchronizability.Comment: 11 pages, 4 figs, submitted to J. Phys. A (proceedings of Complex
Networks 2007
Optimal network topologies: Expanders, Cages, Ramanujan graphs, Entangled networks and all that
We report on some recent developments in the search for optimal network
topologies. First we review some basic concepts on spectral graph theory,
including adjacency and Laplacian matrices, and paying special attention to the
topological implications of having large spectral gaps. We also introduce
related concepts as ``expanders'', Ramanujan, and Cage graphs. Afterwards, we
discuss two different dynamical feautures of networks: synchronizability and
flow of random walkers and so that they are optimized if the corresponding
Laplacian matrix have a large spectral gap. From this, we show, by developing a
numerical optimization algorithm that maximum synchronizability and fast random
walk spreading are obtained for a particular type of extremely homogeneous
regular networks, with long loops and poor modular structure, that we call
entangled networks. These turn out to be related to Ramanujan and Cage graphs.
We argue also that these graphs are very good finite-size approximations to
Bethe lattices, and provide almost or almost optimal solutions to many other
problems as, for instance, searchability in the presence of congestion or
performance of neural networks. Finally, we study how these results are
modified when studying dynamical processes controlled by a normalized (weighted
and directed) dynamics; much more heterogeneous graphs are optimal in this
case. Finally, a critical discussion of the limitations and possible extensions
of this work is presented.Comment: 17 pages. 11 figures. Small corrections and a new reference. Accepted
for pub. in JSTA
Entangled networks, synchronization, and optimal network topology
A new family of graphs, {\it entangled networks}, with optimal properties in
many respects, is introduced. By definition, their topology is such that
optimizes synchronizability for many dynamical processes. These networks are
shown to have an extremely homogeneous structure: degree, node-distance,
betweenness, and loop distributions are all very narrow. Also, they are
characterized by a very interwoven (entangled) structure with short average
distances, large loops, and no well-defined community-structure. This family of
nets exhibits an excellent performance with respect to other flow properties
such as robustness against errors and attacks, minimal first-passage time of
random walks, efficient communication, etc. These remarkable features convert
entangled networks in a useful concept, optimal or almost-optimal in many
senses, and with plenty of potential applications computer science or
neuroscience.Comment: Slightly modified version, as accepted in Phys. Rev. Let
Vertex similarity in networks
We consider methods for quantifying the similarity of vertices in networks.
We propose a measure of similarity based on the concept that two vertices are
similar if their immediate neighbors in the network are themselves similar.
This leads to a self-consistent matrix formulation of similarity that can be
evaluated iteratively using only a knowledge of the adjacency matrix of the
network. We test our similarity measure on computer-generated networks for
which the expected results are known, and on a number of real-world networks
Preferential attachment of communities: the same principle, but a higher level
The graph of communities is a network emerging above the level of individual
nodes in the hierarchical organisation of a complex system. In this graph the
nodes correspond to communities (highly interconnected subgraphs, also called
modules or clusters), and the links refer to members shared by two communities.
Our analysis indicates that the development of this modular structure is driven
by preferential attachment, in complete analogy with the growth of the
underlying network of nodes. We study how the links between communities are
born in a growing co-authorship network, and introduce a simple model for the
dynamics of overlapping communities.Comment: 7 pages, 3 figure
New methodological approach to induce a differentiation phenotype in Caco-2 cells prior to post-confluence stage
BACKGROUND: Various differentiation-inducing agents or harvesting of spontaneously late post-confluence cultures have been used to differentiate the human colon carcinoma Caco-2 cell line. We report a new procedure to generate pre-confluent subcultures of Caco-2 population at various stages of differentiation without altering culture conditions. MATERIALS AND METHODS: Ultrastructural analysis, cell proliferation activity and biochemical markers of differentiation were evaluated at different passages. RESULTS: Subcultures of Caco-2 cells at pre-confluence, exhibiting progressive acquisition of a more benign differentiation phenotype, were generated. Early passages of Caco-2 cells showed a well-developed brush border and incomplete junctional apparatus; subsequent subcultures yielded cell populations with well-developed junctions similar to those of small intestinal cells. CONCLUSION: These culture conditions represent a new versatile model not only to progressively induce the differentiation program in Caco-2 cells at pre-confluence without changes of culture media, but also to explore mechanistic modes of drug transport and tumor development
The psoriatic shift induced by interleukin 17 is promptly reverted by a specific anti-IL-17A agent in a three-dimensional organotypic model of normal human skin culture
Interleukin 17A (IL-17A), mainly produced by the T helper subclass Th17, plays a key role in the psoriatic plaque formation and progression. The clinical effectiveness of anti-IL-17A agents is documented, but the early and specific mechanisms of their protection are not identified yet. The challenge of the present study is to investigate the possible reversal exerted by a specific anti-IL-17A agent on the psoriatic events induced by IL-17A in a three-dimensional organotypic model of normal human skin. Bioptic skin fragments obtained after aesthetic surgery of healthy women (n=5) were incubated with i) IL-17A biological inhibitor (anti-IL-17A), ii) IL-17A, iii) a combination of IL-17A and its specific IL-17A biological inhibitor (COMBO). A Control group was in parallel cultured and incubation lasted for 24 and 48 h epidermal-side-up at the air-liquid interface. All subjects were represented in all experimental groups at all considered time-points. Keratinocyte proliferation and the presence of epidermal Langerhans cells were quantitatively estimated. In parallel with transmission electron microscopy analysis, immunofluorescence studies for the epidermal distribution of keratin (K)10, K14, K16, K17, filaggrin/occludin, Toll-like Receptor 4, and Nuclear Factor kB were performed. IL-17A inhibited cell proliferation and induced K17 expression, while samples incubated with the anti-IL-17A agent were comparable to controls. In the COMBO group the IL-17A-induced effects were almost completely reverted. Our study, for the first time, elucidates the most specific psoriatic cellular events that can be partially affected or completely reverted by a specific anti-IL-17A agent during the early phases of the plaque onset and progression. On the whole, this work contributes to expand the knowledge of the psoriatic tableau
Bloggers Behavior and Emergent Communities in Blog Space
Interactions between users in cyberspace may lead to phenomena different from
those observed in common social networks. Here we analyse large data sets about
users and Blogs which they write and comment, mapped onto a bipartite graph. In
such enlarged Blog space we trace user activity over time, which results in
robust temporal patterns of user--Blog behavior and the emergence of
communities. With the spectral methods applied to the projection on weighted
user network we detect clusters of users related to their common interests and
habits. Our results suggest that different mechanisms may play the role in the
case of very popular Blogs. Our analysis makes a suitable basis for theoretical
modeling of the evolution of cyber communities and for practical study of the
data, in particular for an efficient search of interesting Blog clusters and
further retrieval of their contents by text analysis
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